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In 2017, Wang et al
Curr Opin Biotechnol 19(2):145152
It is contraindicated for use in patients with a personal or family history of medullary thyroid carcinoma and in those with multiple endocrine neoplasia type 2
Overall Effects on Metabolism This all-around metabolic support helps people lose weight and control their diabetes, which allows them to reach their long-term health goals
When compared to the approved TROP2-targeting ADC, sacituzumab govitecan (Trodelvy), the preliminary ORR of 80% in a heavily pre-treated mTNBC cohort appears numerically higher than the ~ 35% ORR reported in the ASCENT trial, though cross-trial comparisons require caution due to the small initial cohort size of JSKN016
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