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For example, Xiang et al

However, tachyphylaxis (tolerance) develops rapidly within 3-5 days of continuous dosing, food intake returns to baseline levels (Cote et al., 2010)

Two-thirds of respondents in the annual budget survey cited cost as the main factor, though theyre also weighing a number of other factors including the need for legislative action, adherence concerns, clinical criteria development and potential side effects, the researchers wrote

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Clinical Results: As one influential analyst noted, Lillys tirzepatide (Zepbound) led clinical trials by ~20% weight loss vs ~14% for Novos semaglutide (Wegovy) ( [18] )