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This nose-to-brain delivery is an area of active research for various therapeutic applications

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Two rules apply to all four

In this case, the B12 shots have started to heal the damaged neurons myelin sheath, but the neural network in which the healed neuron is in, is in a super sensitive state (with extra receptors), so the patient may feel pain or other unpleasant sensations

these organs are able to produce up to 4 grams daily of inositol