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Metformin may result in suboptimal oral vitamin B12 absorption by competitively blocking the calcium-dependent binding of the intrinsic factor-vitamin B12 complex to its receptor

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However, the significance of this molecule acquired more and more relevance due to its regulatory functions in numerous physiological processes, including seed germination, root formation and development, growth, stomatal closure, senescence, flowering, and fruit ripening, but also in the mechanisms of response against biotic and abiotic stresses (Leshem et al

et al., Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity, Nature, 2014