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The ratio of reduced GSH to the disulfide form (GSH/GSSG) within the endoplasmic reticulum ranges from 1:1 to 4:1, whereas the overall cellular GSH/GSSG ratio ranges from 30:1 to 100:1 (Figure 2)
The sample size of the clinical trial was eleven T2DM positive subjects in the L-GSH supplementation arm and seven T2DM positive subjects in the placebo supplementation arm
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By understanding this cascade, clinicians and patients can take proactive steps to protect the nervous system
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