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In our study exercise induced an increase in cellular oxidative stress (as shown by the increase in LPO content) and NO levels, and these factors could account for the increase in oxidative stress

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Binding interaction analysis of Compound 18 with PDE1 revealed that the pyrazolo-pyrimidone core of Compound 18 positioned itself between F424 and L388, establishing H-bonds with Q421

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Presented for research literature review only Murata H et al