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Patients experiencing persistent vomiting should be evaluated for dose adjustment or temporary discontinuation

This finding supports the idea that the mutation in pad2-1 close to the glutamate conjugating residues of GSH1 might influence the affinity of the enzyme for BSO, as it was proposed for cad2-1 54,71

Additionally, TNF- has been shown to induce CCL2 production, and this mechanism is considered significant in metastatic liver diseases [197]