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Acetaldehyde is also responsible for the development of liver disease and is a known neurotoxin that can contribute to cognitive decline with chronic binge drinking
EGb 761 also prevents hearing loss caused by 3-NP in a rat model of acute ototoxicity, which may be related to activation of the expression of Sirtuin 1 (SIRT1) [214]
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The causal relationships of Pro accumulation and significance of GSH metabolism with enhanced tolerance to single stress factor (either metal or salinity) have been reported extensively in separate studies using natural variants, mutants or transgenic plants (Matysik et al., 2002
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