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The clinical and metabolic effects of rapid weight loss in obese pet cats and the influence of supplemental oral Lcarnitine. Journal of veterinary internal medicine 14.6 (2000): 598-608

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Materials and methods : Animals were provided with 1.3 bis( p -Hydroxyphenyl)urea at 12.5, 25, 50, 100, and 200 mg/kg BW

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Exendin-4 inhibits interleukin-1beta-induced iNOS expression at the protein level, but not at the transcriptional and posttranscriptional levels, in RINm5F beta-cells

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29,179,281 Therefore, developing SIRT1-targeted therapies requires careful optimization of dosing, precise control of activity levels, stage-specific intervention timing, tissue- or cell-targeted delivery systems, and integration of NAD + status monitoring to minimize risks and achieve effective outcomes

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