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The 6 chains are covalently linked near their N-terminals through disulfide bonds
Endocrinology 133:233240 Roberge JN, Gronau KA, Brubaker PL (1996) Gastrin-releasing peptide is a novel mediator of proximal nutrient-induced proglucagon-derived peptide secretion from the distal gut
A study conducted in China showed a significant reduction in the recurrence of major cardiovascular events after a median 5.0 years of follow-up with metformin treatment compared to glipizide [14]
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