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About 3-10% of an intravaginal dose of the drug reaches systemic circulation, principally as metabolites

Reconstitution Protocol: Gently run liquid media down the inside vial wall during reconstitution to prevent peptide chain breakdown

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In cytosol, inorganic sulfate is conjugated with adenosine monophosphate by adenosine triphosphate (ATP) sulfurylase to form adenosine 5-phosphosulfate (APS), which is subsequently phosphorylated under the action of APS kinase to form PAPS 10