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Thus, fish uptake the metal from the water, bioconcentrate it in gills and accumulate it in the liver

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J Biol Chem 280:3376633774 Chinta SJ, Kumar MJ, Hsu M, Rajagopalan S, Kaur D, Rane A, Nicholls DG, Choi J, Andersen JK (2007) Inducible alterations of glutathione levels in adult dopaminergic midbrain neurons result in nigrostriatal degeneration

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Therefore, the functionality of this class of enzymes along with other selenium dependent enzymes could be influenced by dietary selenium and adequate levels of glutathione production