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A similar pattern was seen with tirzepatide in the SURMOUNT-4 trial participants who switched from tirzepatide to placebo regained a substantial portion of their weight over 36 weeks
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doi:10.1016/S0140-6736(21)02188-7 Derdemezis CS, Lovegrove JA
Glucagon is the new addition with retatrutide and this is where things get interesting
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