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Of particular concern are new findings linking semaglutide-based medications, including Ozempic, Wegovy, and Rybelsus, to a rare but devastating eye condition
2.1 Role of PDEs in schizophrenia Among the eleven PDE families, PDE1B and PDE10A have emerged as especially relevant in the context of schizophrenia due to their high expression in striatal and cortical circuits governing dopaminergic neurotransmission (Nishi and Snyder, 2010
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Serious side effects were uncommon (0% to 6% in trials), but as with other GLP-1based drugs, rare risks such as pancreatitis, gallbladder problems, or thyroid tumors (in animal studies) remain a concern
If you do experience tiredness, it is usually temporary and related to dietary adjustments
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