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FDAs 2024 evaluation of AOD9604 free base and AOD9604 acetate for possible inclusion on the section 503A bulk drug substances list concluded that the available balance of physicochemical characterization, effectiveness, and safety information weighed against inclusion

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Some recent research suggests metformin may also negatively impact riboflavin (vitamin B2) status - the authors identified a degree of inverse association between metformin and B2 status