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Thirteen subjects completed the study (6 subjects in the placebo group and 7 subjects in the GH group)

Several in vitro and in vivo studies suggest that the ApoE4 protein isoform promotes amyloid pathology and disrupts various aspects of normal brain function, indicating a gain-of-function effect in neurotoxicity associated with ApoE4 (Liu et al., 2013)

Although current research has unveiled multiple mechanisms by which TMAO affects cellular function, its specific roles in different tissues and pathological conditions require further investigation

Targeting serine-glycine-one-carbon metabolism as a vulnerability in cancers

J Am Acad Child Adolesc Psychiatry 52:231240