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Researchers are investigating its potential in reducing cardiovascular risks in individuals with type 2 diabetes, as studies have shown that it can lower the incidence of heart attacks, strokes, and other cardiovascular events

In the CHARISMA trial, patients with established atherosclerotic cardiovascular disease (symptomatic) or multiple risk factors for atherosclerotic disease (asymptomatic), but without active acute coronary syndrome, were randomly assigned to receive either clopidogrel plus aspirin or placebo plus aspirin

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The absence of a gallbladder does not fundamentally prevent these medications from working or create an automatic safety concern