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MATERIALS AND METHODS: STEP 1 (NCT03548935) randomized 1961 adults with a body mass index 30 kg/m2 (or 27 kg/m2 with 1 weight-related co-morbidity) without diabetes to 68 weeks of once-weekly subcutaneous semaglutide 2.4 mg (including 16 weeks of dose escalation) or placebo, as an adjunct to lifestyle intervention
Data evaluated by the trial product estimand are therefore more appropriate for use in cost-effectiveness analyses, as the confounding clinical and cost impacts of additional medications (for example, additional reductions in HbA1c and the acquisition costs of these medications) are excluded, allowing a more direct comparison of the two evaluated interventions
