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( C ) Schematic of IRI protocol and ( D ) percentage of LVDP recovery of isolated WT mouse hearts with the sAC inhibitor KH7 (20 mol/L) or the tmAC inhibitor Ddox (50 mol/L) prior to perfusion with buffer only (Cntl), scrambled(2836), GLP-1(2836), or GLP-1 ( n = 3/group)
Importantly, ROS generation is associated with A-protein aggregates, which are known to promote synaptic dysfunction (Ahmad et al., 2018)
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Unlike older therapies that target one or two receptors, Retatrutide activates three receptors: GLP-1, GIP, and glucagon
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