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Madrigals parallel clinical investment in the MAESTRO-NASH OUTCOMES trial, while expensive, reflected the recognition that GLP-1 receptor agonists were entering Phase 3 MASH programs and that outcomes data would be the long-term competitive moat

Tendon and Ligament Repair Moderate to Strong Evidence Evidence Rating: Moderate-Strong (Several animal studies, some independent replication) Research support for musculoskeletal healing is substantial: Achilles tendon injuries Ligament damage (MCL, ACL) Rotator cuff healing General tendinopathy Surgical repair enhancement The FAK-paxillin mechanism and VEGF upregulation provide clear biological rationale for these effects