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What is needed is a large, well-designed trial that compares a GLP-1 agonist to placebo in migraine patients, stratified by weight status, migraine subtype, and other relevant variables
Unger J, Kaltoft M, Kolhe D, Panda JK, Sargin ME, Wolthers BO, Zoghbi M
This creates a clinical flow where patients initiate on oral therapy, stabilize, and either remain on pills or step up to higher-efficacy injectables based on their clinical needs, a tiered treatment model that expands the overall market rather than simply redistributing it
Therapeutic and Bioactive Peptides in Musculoskeletal Medicine: A Narrative Review
10.1016/j.neuroscience.2014.11.025 26
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