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After menopause, fat shifts to the abdomen, particularly the visceral compartment surrounding the organs
8.6 Renal Impairment The dosing requirements for SYMLIN are not altered in patients with mild (creatinine clearance [ClCr] 60-89 mL/min), moderate (ClCr 30-59 mL/min) or severe renal impairment (ClCr 15-29 mL/min)
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