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Maslak P, McKenzie S, Scheinberg D, Andreeff M , Clarkson B
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Novel 2-phenylquinolin-7-yl-derived imidazo[1,5-a]pyrazines as potent insulin-like growth factor-I receptor (IGF-IR) inhibitors
The resulting acyl-phosphate intermediate undergoes nucleophilic attack by the -amino group of cysteine, which may be activated by an active site glutamate
These genetic changes can affect levels of glutathione, along with dietary glutathione and nutrients required for glutathione metabolism
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