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The standard dosage is 20-40 mg/kg of body weight for 3-6 months once or twice in a day and best if taken at night 2-3 hours after the last meal for better absorption
Mechanistic sampling of intestinal tissue during this trial would best validate the reparative hypothesis if analyses include tight junction protein expression (e.g., claudins, occludin, zonula occludens-1), histologic healing assessments using validated indices (e.g., Geboes score, Robarts Histopathology Index), and intestinal permeability assays such as the lactulose-mannitol ratio
You have certain bad bacteria in your intestines
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