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Simultaneous quantification of these two oxidized metabolites by electrochemical HPLC assay demonstrated that human P450 2E1 selectively oxidizes APAP to NAPQI (determined as glutathione conjugate, GS-APAP), whereas human P450 2A6 selectively oxidizes APAP to 3-OH-APAP (Chen et al., 1998)

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Cardiomyopathies (CM), a subset of CVD, are defined by structural and functional myocardial changes such as altered size, shape, or wall thickness arising from either ischemic (coronary artery disease-related) or non-ischemic origins (3, 4)