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Inhibition of PHGDH reduces the production of -ketoglutarate (-KG), serine and NADPH, and induces cell death by elevating ROS levels (131)
Zhang et al., 2025)
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GHK-Cu occurs naturally in the body and plays a key role in signaling collagen production, wound healing, and cellular regeneration
N 1 -acetylspermine and N 1 -acetylspermidine are converted to spermidine and putrescine, respectively, by polyamine oxidase (encoded by the PAOX gene) along with the production of H 2 O 2 and 3-acetylaminopropanal (3Ac-AP or 3-AAP)
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