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The expression of the VD metabolism genes CYP2R1 and CYP27A1 (25-hydroxylase), CYP27B1 (1--hydroxylase), and vitamin D receptor (VDR) were downregulated in the livers of mice fed an HFD (GSH- deficient) compared with control diet-fed group

Research Summary IGF-1 LR3 is a recombinant long arginine analog of insulin-like growth factor 1 with a 13 amino acid N-terminal extension that reduces IGF-binding protein affinity, resulting in a ~120-hour half-life versus 15 hours for native IGF-1

This may help alleviate PD-related symptoms and slow down the progression of Parkinsons disease

In contrast, the second approach explored replacing the quinazoline nucleus with alternative templates such as phthalazine, cinnoline, and quinoline

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