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For chromatographic metabolite separation, a Vanquish ultra-performance liquid chromatography (UPLC) system was coupled to a Q Exactive HF (QE-HF) mass spectrometer equipped with heated electrospray ionization (HESI

There is no doubt that the GLP-1 landscape has significantly evolved in the last few years, from the early days of single hormone agonists like semaglutide to multi-hormone agonists of today such as tirzepatide and retatrutide

Erythrocytes from control subjects were incubated with 10 mmol /L [14C]glucose with or without the addition of methylene blue

Marginal structural models were used to evaluate the association between GLP-1RAs and MACE risk, accounting for time-varying confounding using inverse probability weighting, although residual confounding cannot be fully excluded

In HCC driven by obesity and nonalcoholic steatohepatitis, the downregulation of CPT2 leads to the accumulation of acylcarnitines, among which C18:1-carnitine enhances spheroid formation by HCC cells through STAT3 activation, indicating that the accumulation of acylcarnitine can promote the development of liver cancer [212]