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And, in general, despite successfully increasing the amount of NAD + , high doses of NR, as an example, havent translated into the expected NAD+ benefits in metabolic health in humans.[51,52] In keeping with the Goldilocks principle and complexity science tenets, a more moderate dose, while also optimizing how NAD is made and used in the body, might be a more sound approach

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It has also been said not to raise IGF-1 levels, which helps reduce worries about cancer risks