Mast cell activation syndrome, or MCAS, is an immunological condition where the mast cells in the body release excessive amounts of chemical mediators such as histamine, leading to symptoms such as hives, flushing, rashes, swelling, low blood pressure, dizziness, brain fog, breathing difficulties, and even anaphylaxis
Two possibilities are that DHA concentrations are extremely low in compartments such as the chloroplast and cytosol or that rate constants for the chemical reaction are much slower in the crowded cellular environment than those measured in dilute solutions in vitro, making enzymes necessary to favour the reaction between DHA and GSH
doi: 10.1084/jem.20181965
It was a controlled assessment of the exact scenario being questioned
This precise targeting capability allows researchers to more effectively select candidates for further functional validation and drug development