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Based on the patient population we see in Doral, the strongest candidates typically include: Patients with chronic or multi-site injuries: TB-500s systemic distribution makes it particularly relevant for patients with injuries across more than one joint or tissue type, where localized injection alone would require multiple sites per session

While researchers use APEX2 or TurboID targeted to the mitochondrial matrix or outer membrane to catalog internal cargo packaged into EVs prior to release, capturing the transient membrane budding interface of a vesicle remains difficult