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NNMT acts as a primary metabolic gatekeeper, predominantly active in fat tissue and liver cells, where it methylates nicotinamide (NAM) using S-adenosyl-L-methionine (SAM) as a methyl donor

5-Amino-1MQ is a small molecule studied for its role as an inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme linked to metabolic regulation and cellular energy balance