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Cagrilintide was specifically engineered to retain strong affinity for AMY1R and AMY3R while avoiding the fibrillation problems that plague natural amylin
Secondary outcomes Five included studies comprising 3605 patients reported change in MCV, four studies comprising 140 patients reported change in homocysteine levels, four studies comprising 3588 patients reported change in platelets count, and only three studies with 3430 patients reported change in WBC count
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Gastrointestinal applications show particular promise given the peptides origin, with documented repair of mucosal damage, restoration of tight junction integrity, and protection against NSAID-induced ulcers
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