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GLP-1R agonists that elicit less internalization produce less nausea, an adverse effect that often limits dosing ( The present study may be extended by measuring the interaction between the wild-type and chimeric receptors and arrestin-2 (-arrestin-1)

For Canadian researchers following the metabolic peptide field, cagrilintide and the amylin analog category warrant attention as the field continues to expand beyond single, dual, and triple agonist compounds

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