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144 Among them, P-gp/ABCB1, 145 MDR-associated proteins (MRPs/ABCCs), 146 and BCRP/ABCG2 147 are most extensively studied

It was first isolated from human plasma, where it naturally occurs at concentrations of around 200 ng/mL at age 20, declining to approximately 80 ng/mL by age 60

Conclusions Nrf2 is a master regulator of several protective stress response pathways and it is not surprising that it became a highly competitive target for pharmacological modulation (Cuadrado et al