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Stem Cell Rep 8 (3), 509518
The antidepressant sertraline inhibits translation initiation by curtailing mammalian target of rapamycin signaling
By increasing GSH serum levels, enhanced performance may result
3 Results In this study, we aimed to determine if three drugs from the SSRI family (sertraline, fluoxetine, and citalopram), commonly used as antidepressants (Figure 1, right panel), can be repurposed as inhibitors of MRP1 and MRP7 transporters (Figure 1, left panel) to overcome MDR in cancer cells
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