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Berberine targets intracellular energy pathways, while semaglutide modulates hormonal signaling and appetite centers

More recently, intestinal organoid models and real-time EEC reporter mice have demonstrated the complexity and heterogeneity of EEC differentiation and gene expression 85,86

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By analyzing results separately by rating scale, conducting prespecified subgroup and meta-regression analyses, and assessing robustness through sensitivity tests, this study provides a comprehensive evaluation of the evidence