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The finding was further supported by c-met-binding experiments, in which HGF was pre-treated with GSSSG and LASSS at the same molar ratio 1:4000 at which the satellite-cell activation index was rescued to a level comparable to that of non-nitrated regular HGF, as shown in Figure 1d, followed by exposure to peroxynitrite (1:2000) and evaluated for c-met-binding by a sandwich ELISA-like assay on recombinant c-met-Fc chimera (Figure 1e, left column

R.IqbalA.LinaresE.SilvaD

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Ten participants received high-dose intravenous ascorbate (75100 grams per treatment) along with standard chemotherapy (paclitaxel and carboplatin) for six months

PMID: 38383406 Proc Natl Acad Sci U S A Mitochondrial ROS triggers mitophagy through activating the DNA damage response signaling pathway