This phenomenon appears related to the speed of glycemic improvement rather than a direct toxic effect on ocular tissues
These include vitamin E, pioglitazone (PPAR agonist), obeticholic acid (farensoid X receptor agonist), cenicriviroc (CCR2/CCR5 antagonist), selonsertib (apoptosis signal-regulating kinase 1 inhibitor), and liraglutide (glucagon-like peptide 1 analogue) [136,137,138,139,140,141]
GLS2 exhibits a distinctly divergent expression pattern in comparison to GLS1, which functions as an environmentally dependent tumour suppressor gene and is associated with a favourable prognosis [18]
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Because of that, many providers use it off-label for obesitybut insurance often wont pay if you dont have a diabetes diagnosis