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Inactivation of MSMO1 or its partner NAD(P) dependent steroid dehydrogenase-like (NSDHL) sensitizes various tumor cell lines (such as A431, SCC61, SCC68, SCC25, PC9, FaDu, Detroit and MCF12F) to epidermal growth factor receptor (EGFR) inhibitors by promoting EGFR degradation via lysosomal trafficking
These include vitamins (C, E, and -carotene), some metallo-enzymes including glutathione peroxidase (GPx, containing selenium), catalase (CAT, containing iron), superoxide dismutase (SOD, containing copper, manganese and zinc)
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It deserves careful attention
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