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Metabolism 2007;56(8):1118-1123
FDA approves new drug treatment for chronic weight management, first since 2014, Food and Drug Administration (2021) FDA approves first treatment to reduce risk of serious heart problems specifically in adults with obesity or overweight, Food and Drug Administration (2024) Wegovy prescribing information, Food and Drug Administration (2024) Medically accurate: SingleCares Medical Review Board analyzes all of our content to confirm its in line with current medical advice
Krug HF, Nau K
- Increased -cell proliferation - Enhanced cell survival with reduced apoptosis - Restoration of islet mass in preclinical metabolic models - Improved glucose stimulated insulin secretion This synergy has ensured success in regenerative therapies for type 1 and type 2 diabetes
However, triple receptor agonism, or agonism/antagonism combinations, can be achieved not only though unimolecular triple agonists, but also by combining mono- and dual-agonists
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