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Some may be on the pathway to professional or elite status

It is currently unclear if the resistance to GLP-1 is primarily due to impaired receptor expression, reduced signaling in the gut-brain axis and/or intestinal dysbiosis

And make sure your water intake is sufficient, especially since GLP-1 medications not only reduce hunger but can also reduce feeling thirsty

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Companies in this space include mitochondrial uncouplers with enhanced safety profiles (Rivus, Continuum), GDF15 targeting drugs (Novo, Lilly, Janssen), anti- activin II receptor mAb (Versanis), mir-22 inhibition (Resalis Tx) and gut-brain axis modulators (Kallyope)