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However, excessive ROS cause oxidative damage to DNA, proteins, lipids, organelles, and cell membranes, which may trigger cell death pathways such as apoptosis, autophagy, ferroptosis, pyroptosis, necrosis, and ultimately lead to follicular atresia and reproductive aging [115, 116, 249, 255,256,257,258]

Similarly, the administration of 200 micrograms per day of selenium for 8 weeks in PCOS patients had beneficial effects on their insulin metabolism parameters, triglycerides and very low-density lipoprotein-C (VLDL-C) levels (143)

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