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doi: 10.1016/j.molmet.2021.101351 148 American Diabetes Association
All these risk factors have a common characteristic, they are associated with a continuous state of oxidative stress and inflammation, excessive production of free radicals (reactive oxygen and nitrogen species) and endothelial cell dysfunction leading to cardiovascular disease and respiratory failure
Most gallstones are composed primarily of cholesterol, but a small percentage are made mainly of bilirubin and are known as pigment stones
Extreme deficits (800-1,000 calories below maintenance) are unnecessary and counterproductive because they increase muscle catabolism and metabolic adaptation
The two enzymatic activities are a hydratase and a dehydrogenase
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