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The goal is to balance therapeutic benefit with tolerability
Similar to the findings of other studies in the STEP trial program 7,27 , exploratory outcomes showed that in the semaglutide group 80% of participants with prediabetes at baseline reverted to normoglycemia by the end of the trial (compared with 37% of those receiving placebo), while 99% of participants with normoglycemia at baseline maintained normoglycemia at the end of the trial (compared with 86% with placebo)
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Samples were extracted in 10 mM Tris-HCl (pH 7.6) with 20 mM iodoacetic acid and pre-incubated at 25 C for 30 min for GPX activity assay
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