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Preferential tissue distribution to kidneys, liver, and gastrointestinal tract aligns with observed therapeutic effects in animal studies
We measured the markers of cardiac hypertrophy including MYH7 and ANP, NLRP3 inflammatory signaling pathway including NLRP3, Caspase-1, and IL-18 by Western-blot, and we detected the expression MYH7, ANP, NLRP3, and IL-18 by IHC in Sham group, TAC group, TAC + semaglutide group, and TAC + semaglutide + HCQ group, respectively
doi: 10.1155/2022/8387271 9 Skrzypiec-SpringMPokrywkaABombalaWBerezovskaDRozmusJBrawanskaKet al
(Warnakulasuriya et al., 2021)
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