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Dr Max Taquet said: "Our study is observational and these results should therefore be replicated in a randomised controlled trial to confirm and extend our findings
Excessive cytokine activity, including IL-1, IL-6, and TNF-, amplifies these alterations (Hughes et al
Your doctor will assess which dose of Mounjaro to start you on, depending on which dose of Wegovy you are currently on or were previously taking
Author contributions RG: Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Software, Visualization, Writing original draft
Protocol 1: moderate weight loss (10-15% body weight) Goal: Steady, sustainable weight loss with minimal side effects Tirzepatide approach: Standard escalation to 5-7.5 mg Hold at the dose where you achieve consistent weekly loss of 0.5-1% body weight Expected timeline: 24-36 weeks to target Likely maintenance dose: 5-7.5 mg Retatrutide approach: Standard escalation to 4 mg 4 mg delivered 12.9% weight loss at 24 weeks in trials Hold at 4 mg if achieving target rate Expected timeline: 20-30 weeks to target For moderate goals, both compounds work well at their lower dose ranges
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