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Nausea is common but usually tolerable at this low starting dose
Pivotal data: STEP-1 (Wilding et al., NEJM 2021) reported 14.9 percent body-weight reduction at 2.4 mg weekly over 68 weeks, and SELECT (Lincoff et al., NEJM 2023) was the first demonstration that a GLP-1 agonist reduces cardiovascular events in a population without diabetes (20 percent MACE reduction)
G., Mori, C., Szucs, T
The dose is generally weight-based (1.6 mcg/kg/day for full replacement)
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