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The ER also communicates with mitochondria via signaling from the unfolded protein response (UPR), which is activated by ER stress and signals through the three ER-resident stress sensors IRE1, PERK, and ATF6 (Walter & Ron, 2011)
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Bloating varies by person, but studies show that about 40-70% of GLP-1-treated patients experience some form of gastrointestinal side effects, including nausea & vomiting, diarrhoea, constipation and abdominal pain
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