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The removal of this region and the multivalent presentation on a ferritin nanoparticle significantly improved DCFHPs neutralizing potency in mice relative to the use of unedited spike, since it allows the immune system to not get distracted by creating an antibody response against a region that is ultimately nonneutralizing [134]
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For example, in the context of vascular anti-inflammatory response pertaining to atherosclerosis, GLP-1RA liraglutide was found to inhibit human plasminogen activator inhibitor type-1 secondary to tumor necrosis factor alpha (TNF-alpha) signaling [45]
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